What is MethylAction?

MethylAction is an R package for detecting differentially methylated regions (DMRs) from enrichment-based techniques for sequencing DNA methlyation genome-wide. These techniques include MBD-isolated Genome Sequencing (MiGS), MBD-seq, and MeDIP-seq.

Key Features:

How to Use MethylAction

We have created a step-by-step how to for new users to learn the essential functions of the R package and perform an analysis on example data.

Step-by-Step How To:

For more advanced options, please refer to the function manual. This information is also available from within R using the "?" command.

Function and Reference Manuals:


Please refer to our open access manuscript to learn more about MethylAction. Please cite this work if MethylAction is useful in your research.

Bhasin, JM, Hu, B, and Ting, AH. (2016). MethylAction: detecting differentially methylated regions that distinguish biological subtypes. Nucleic Acids Res. 44, 106-116. PMID: 26673711. PMCID: PMC4705678.

Contact and Help

Please open an issue on the MethylAction GitHub Issues page for questions, bug reports, or enhancement requests.

You may also contact the package author with questions or feedback: